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Pharmacist Evaluating Examination sample question Biomedical sciences PART 1

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Pharmacist Evaluating Examination sample question Biomedical sciences PART 1

The Pharmacy Examining Board of Canada

PHARMACEUTICAL SCIENCES

46 .Once daily dosing of aminoglycosides is effective due to:

  1. prolonged residence of the antibiotic in the body.
  2. post-antimicrobial effect.
  3. enhanced tissue accumulation.
  4. reduced renal clearance.
  5. higher peak-trough differences.

47 .How much NaCl is required to make 100 mL of isotonic 0.5% phenylephrine HCl solution? (NaCl

equivalent of phenylephrine HCl is 0.32)

  1. 100 mg
  2. 300 mg
  3. 500 mg
  4. 740 mg
  5. 900 mg

48 .Which of the following nonparenteral routes of administration yields the best bioavailability of

biotechnology protein drugs?

  1. Oral
  2. Rectal
  3. Ocular
  4. Pulmonary
  5. Transdermal

49 .Theoretically, the shelf life of a pharmaceutical tablet preparation is best measured by a change in

which of the following?

  1. Permeability of the drug
  2. Dissolution of the drug
  3. Strength of the drug
  4. Solubility of the drug
  5. Partitioning of the drug

50 .A drug that is considered to be low clearance and is metabolized entirely by the liver is sensitive to

changes in:

  1. drug binding to plasma proteins.
  2. bile secretion.
  3. hepatic blood flow.
  4. renal blood flow.
  5. p-glycoprotein transport activity.

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