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Pharmacist Evaluating Examination sample question Biomedical sciences PART 1

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The Pharmacy Examining Board of Canada

PHARMACEUTICAL SCIENCES

22 .Which of the following medications induces an isoform of cytochrome P450?

  1. Carbamazepine
  2. Clarithromycin
  3. Amiodarone
  4. Metronidazole
  5. Bosentan

23 Diazepam Injection U.S.P

Diazepam 5 mg/ml

Ethanol 10%

Propylene glycol 40%

Benzyl alcohol 1.5%

Water for Injection qs 100%

In the formulation given above, propylene glycol functions as a(n):

  1. emulsifier.
  2. antioxidant.
  3. cosolvent.
  4. buffer.
  5. preservative.

24 .Which of the following directly influences the in vitro physical stability of an oil-in-water emulsion in

which the drug is incorporated in the dispersed phase?

  1. Amount of preservative added
  2. Molecular weight of the drug
  3. Solubility of the emulsifier in water
  4. Particle size of the internal phase
  5. Type of suspending agent used

25 .Abatacept acts by:

  1. stimulating adenosine receptors.
  2. binding to MHC Class II on B cells.
  3. inhibiting B cell receptors.
  4. activating T cell receptors.
  5. binding CD80/86 on antigen-presenting cells.

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