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Pharmacist Evaluating Examination sample question Biomedical sciences PART 1

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Pharmacist Evaluating Examination sample question Biomedical sciences PART 1

The Pharmacy Examining Board of Canada

PHARMACEUTICAL SCIENCES

38 .The organophosphates commonly found in insecticides are thought to act by which of the following

mechanisms?

  1. Combining with acetylcholine
  2. Potentiating the action of acetylcholinesterase
  3. Forming a very stable complex with acetylcholinesterase
  4. Reacting at the cholinergic receptor
  5. Preventing the release of acetylcholine from the nerve ending

39 .Which of the following is a selective adrenergic beta1-blocker with endothelium-dependent

vasodilating properties?

  1. Nebivolol
  2. Metoprolol
  3. Acebutolol
  4. Nadolol
  5. Carvedilol

40 .Which of the following statements is correct regarding the use of monoclonal antibody drug

therapies?

  1. Flu-like symptoms commonly occur at the start of therapy.
  2. T cells are stimulated and will initiate a host rejection process.
  3. Adalimumab is a murine-derived immunoglobulin monoclonal antibody product.
  4. Use of chimeric monoclonal antibodies is associated with increased immunogenicity.
  5. Use of Fc fragments avoids raising an immune response against the FAB part.

41 .In some parenteral formulations, sodium metabisulphite is included as:

  1. an antioxidant.
  2. a chelator.
  3. a solubilizer.
  4. a cosolvent.
  5. an emulsifier.

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