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Pharmacist Evaluating Examination sample question Biomedical sciences PART 1

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The Pharmacy Examining Board of Canada

BIOMEDICAL SCIENCES

16 .Achieving a high level of herd immunity is an important public health strategy because it:

  1. reduces immunization costs in communities.
  2. enhances individual immunologic responses.
  3. facilitates animal handling.
  4. protects people who cannot be immunized.
  5. requires fewer booster doses.

PHARMACEUTICAL SCIENCES

17 .All of the following statements concerning the lyophilization of a parenteral product are correct,

EXCEPT:

  1. there is minimal loss of activity in heat labile materials.
  2. the liquid must be frozen to below the eutectic temperature.
  3. the solute usually forms an amorphous glass.
  4. the eutectic temperature is the freezing point of the drug solution.
  5. water is removed from the frozen mixture by sublimation.

18 .Dopamine is useful in the treatment of cardiogenic shock because it:

  1. selectively dilates renal and mesenteric vascular beds.
  2. does not induce peripheral vasoconstriction.
  3. decreases the force of myocardial contraction.
  4. delays the atrioventricular (AV) conduction time.
  5. prolongs the QT interval on the ECG.

19 .Concentration of a drug in breast milk exceeds that in plasma, if the drug:

  1. is basic.
  2. is protein bound.
  3. is acidic but not protein bound.
  4. has a small volume of distribution.
  5. has a large volume of distribution.

20 Drug A is administered by continuous IV infusion at a rate of 2 mg/min. It has an average half-life of

1.5 h and a volume of distribution of 150 L in an average 70 kg patient. Using this information, what

is the steady-state concentration of Drug A in plasma?

  1. 1.5 mg/L
  2. 1.7 mg/L
  3. 2.1 mg/L
  4. 2.4 mg/L
  5. 2.7 mg/L

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