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Pharmacist Evaluating Examination sample question Biomedical sciences PART 1

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Pharmacist Evaluating Examination sample question Biomedical sciences PART 1

The Pharmacy Examining Board of Canada

PHARMACEUTICAL SCIENCES

32 .Factors that determine bioequivalence of two brands of a drug include the:

  1. taste of the preparations.
  2. physical appearance of the preparations.
  3. pharmacokinetic parameters of the preparations.
  4. cost of the preparations.
  5. package size of the preparations.

33 .The total body clearance of a drug is 200 mL/min in a normal healthy adult and the renal clearance is

10 mL/min. This is most likely explained by the fact that the drug:

  1. is extensively metabolized.
  2. accumulates in patients with moderate renal failure
  3. undergoes significant entero-hepatic recycling.
  4. is not bound to plasma proteins.
  5. is concentrated in adipose tissue.

35 .Imatinib is an anticancer agent used in the treatment of chronic myelogenous leukemia that acts by

inhibiting the activity of:

  1. tyrosine kinase of Bcr-Abl.
  2. tyrosine kinase of HER-2.
  3. tyrosine kinase of FGFR.
  4. histone deacetylases.
  5. serine/threonine kinase mTOR.

36 .Which of the following diuretics is used to block the Na+

  1. Furosemide
  2. Hydrochlorothiazide
  3. Spironolactone
  4. Acetazolamide
  5. Amiloride

37 .Atropine poisoning can be recognized by all of the following signs or symptoms, EXCEPT:

  1. dry skin.
  2. flushed appearance.
  3. delirium and restlessness.
  4. mydriasis.
  5. diarrhea.

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